Health & Fitness Alzheimer's Gene Is Neutralised In Human Brain Cells For The First Time

12:30  12 april  2018
12:30  12 april  2018 Source:   Huffington Post UK

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Not only that, but they also managed to neutralize the gene so that it did not lead to Alzheimer ’ s development. Having two copies increases the risk by 12-fold. This is because the gene produces a certain kind of mutated protein that damages human brain cells .

Scientists have claimed an important breakthrough in the battle against Alzheimer ’ s after neutralising the most significant gene responsible for the disease for the first time . A team in California successfully identified the protein associated with the

  Alzheimer's Gene Is Neutralised In Human Brain Cells For The First Time © Provided by Shutterstock A gene which can reportedly increase the chances of you developing Alzheimer’s has been neutralised by scientists for the first time.

Having just one copy of the gene, called apoE4, can double your chances of developing Alzheimer’s disease later in life, while having two copies of it can increase your risk a whopping 12-fold.

The team from Gladstone Institutes were able to completely neutralise the gene’s effects by creating a compound that transformed the structure of the apoE4 protein into the completely harmless apoE3 one.

What sets this study apart from so many Alzheimer’s studies however is that the tests were actually carried out on human brain cells, not mice.

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Scientists have claimed an important breakthrough in the battle against Alzheimer ’ s after neutralising the most significant gene responsible for the disease for the first time . A team in California successfully identified the protein associated with the high-risk apoE4 gene and then managed to

Scientists have claimed an important breakthrough in the battle against Alzheimer ’ s after neutralising the most significant gene responsible for the disease for the first time . The experiment is particularly significant because it took place in human cells . Yadong Huang, who led the study, which

Lead author Yadong Huang, MD, PhD and his team were able to use skin cells donated by Alzheimer’s patients and create neurons from them. These neurons then became the testbed for their treatment of the the apoE4 gene.

a close up of a coral © Altayb via Getty Images It’s not entirely clear why apoE4 has such a harmful affect on the brain but what they did see was that the misshapen protein cannot function properly within the human brain and as a result creates the build-up of protein tau and of amyloid peptides that we see in Alzheimer’s patients.

For Huang the real breakthrough was that by testing their methods on human cells they were able to overcome one of the big hurdles that scientists face when trying to treat Alzheimer’s.

“Drug development for Alzheimer’s disease has been largely a disappointment over the past 10 years,” says Huang.

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against Alzheimer ’ s after neutralising the most significant gene responsible for the disease for the first time . Huang and his colleagues went straight for human brain cells rather than the traditional mouse trial because they realised the presence of the apoE4 gene does not change the production of

A gene strongly associated with Alzheimer ’ s disease has been neutralised in human brain cells Scientists have ‘turned off’ a protein associated with the apoE4 gene , which damages nerve cells ‘But when we first started we knew almost nothing about Alzhiemer’s and now we understand a huge

“Many drugs work beautifully in a mouse model, but so far they’ve all failed in clinical trials. One concern within the field has been how poorly these mouse models really mimic human disease.”

Huang is now working with collaborators in academia and the pharmaceutical industry to improve the compounds so that they can begin full human testing.

Related: 10 surprising Alzheimer’s predictors

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